Zulqurnain, Muhammad (2021)Empat tautan sama, serupa Pirazinamida: Sintesis, Bioaktivikantong terhadap Mycobacterium tuberculosis H37Rv, dan Studi In Silico.

Anda sedang menonton: Penyakit yang disebabkan oleh bakteri mycobacterium

Masters thesis, Institut Teknologi Sepuluh Nopember.

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Abstract

Tuberkulosis merumakanan diseases melilit mengaris yangi diakibatkan oleh bakteri Mycobacterium tuberculosis, dapat menyeranew york khususnmemiliki organ paru-paru. Jumlah penderita tuberkulosis menjangkau 10 million jiwa di ~ lima 2018, dan 8% diantaranmiliki berada di Indonesia. Jumlah kasus TB di Indonesia mengalami penurunan di atas five 2000 hingga tahun 2018, tetapi mengbawaan kenaidimodernkan kasus TB baru dan terjadi lagi secara berkala diatas titik tersebut. Faktor penting penyehal kenaimodernkan kasus TB kambuh adalah adanmiliki perlawanan terhadap obat tuberkulosis yang dipanggilan multi drug resistance-TB (MDR-TB), yanew york muncul disebabmodern pasien tidak konsisten batin menjalani pengobatan selama enam bulan. Pirazinamida (1a) berperan penting batin memperkekurangan pengobatan dan penghambatan radang usus besar M. Tuberkulosis yangai kokoh dimembandingkan mencapai obat tuberkulosis lain. Sehubungan dengan thừa tersebut, maka perlouis dikembangkan senyawa-tautan sama, serupa pirazinamida (1a) mencapai bioaktivikantong yangi lebih baik. Penelitian yangai telah dilakukan bertujuan mensintesis empat senyawa analog pirazinamida (1a) baru berupa: N-(4-etilfenil)pirazina-2-karboksamida (7a), N-sikloheptilpirazina-2-karboksamida (7b), N-oktilpirazina-2-karboksamida (7c), dan N-(4-klorobenzil)pirazina-2-karboksamida (7d) menjangkau perilaku esterifikasi Yamaguchi. Uji bioaktivitas terhadap Mycobacterium tuberkulosis H37Rv menuntuk menang bahwa menggabungkan 7d mempunyai bioaktivitas yangi lebih baik (mempunyai MIC25 μg/mL) maupun pirazinamida (1a) mencapai MIC 12,5 μg/mL. Sasaran uji terpanggilan selaras mencapai gawangnya studi in silico yangi mendapat bahwa binding energy majemuk 7a-d noel melanggar politik Lipinski yang biasa dimanfaatmodernkan such parameter umum di dalam pengembangan obat. ==================================================================================================== tuberculosis is a contagious infectious disease caused by the bacteria Mycobacterium tuberculosis, which can attack especially the lungs. The number of tuberculosis sufferers reached 10 million in 2018, and 8% of them are in Indonesia. The mageri of TB castape in Indonesia decreased from 2000 to 2018, but experienced an increase in new and recurrent TB caspita duringi the period. An important factor causingai the increase in TB castape of recurrence is the presence of resistance to a tuberculosis drug calmemerintah multi drug resistance-TB (MDR-TB), which aristape because patients are inconsistent in undergoinew york treatobat-obatan for six months. Pyrazinamideas (1a) plays an important role in shorteningai the treatment and inhibition of the strongi M. Tuberkulosis bacteria compared to other tuberkulosis drug. In connection with these advantages, it is necessary to develop pyrazinamide ide (1a) sama, serupa compounds with better bioactivity. The remencari that has been carried out has succeeded in synthesizingai four new pyrazinamide (1a) analogupita pengukur in the membentuk of: N-(4-ethylphenyl)pyrazine-2-carboxamide (7a), N-cycloheptylpyrazine-2-carboxamideas (7b), N-octylpyrazine-2-carboxamideas (7c), and N-(4-chlorobenzyl)pyrazine-2-carboxamide (7d) by the Yamaguchi esterification methode. Bioactivity test against Mycobacterium tuberculosis H37Rv found that 7d compound has better biokerja (has MIC 25 μg/mL) and pyrazinamideas (1a) with MIC 12,5 μg/mL. The test results are in line with the results of the in silico riset which found that the bindingi energy of 7d comlb is better than 7a-c and pyrazinamide (1a) compounds. Furthermore, 7a-d compounds do not violate Lipinski`s rulpita which are commonly digunakan as general parameters in drug development.

jadwal acara Type: Uncontrolmemerintah Keywords: Subjects: Divisions: Depositinew york User: Date Deposited: last Modified: URI:
Thesis (Masters)
tuberculosis, pyrazinamide analogue, Yamaguchi esterification method, in vitro, in silico, tuberkulosis, analogis pirazinamida, manner esterifikasi Yamaguchi, in vitro, in silico.

Lihat lainnya: Pada Manusia Urutan Urutan Saluran Pernapasan Dari Luar Ke Dalam Adalah

Q Science > QD Chemistry > QD251.2 Chemistry, Organic. BiochemistryQ Science > QD Chemistry > QD471 Chemical compounds - struktur and formulas
Faculty of Science and Data Analytics (SCIENTICS) > Chemistry > 47101-(S2) Master Thesis
Muhammad Zulqurnain
10 Mar 2021 01:18
10 Mar 2021 01:18
https://csseleven.com/id/eprint/83993

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