INVOKANA is a prescription medication utilized: INVOKANA is not utilized to reduced blood glucose (sugar) in grownups with kind 2 diabetes mellitus with serious kidney problems.It is not recognized if INVOKANA is reliable as well as risk-free in kids under 18 years old.

What are the feasible negative effects of INVOKANA?

INVOKANA might trigger major adverse effects consisting of:

See & ldquo; What is one of the most crucial details I should understand about INVOKANA?” & rdquo;

reduced blood sugar level(hypoglycemia). If you take INVOKANA with one more medication that can create reduced blood glucose, such as a sulfonylurea or insulin, your danger of obtaining reduced blood glucose is greater. The dosage of your sulfonylurea medication or insulin might require to be reduced while you take INVOKANA.

Symptoms and signs of reduced blood glucose might consist of:

headacheconfusionhungershaking or sensation jitterydrowsinessdizzinessfast heartbeatweaknessirritabilitysweating a major however unusual microbial infection that triggers damages to the cells under the skin (necrotizing fasciitis) in the location in between as well as around the rectum and also genital areas (perineum). Necrotizing fasciitis of the perineum has actually occurred in individuals that take INVOKANA. Necrotizing fasciitis of the perineum might cause a hospital stay, might need several surgical treatments, and also might bring about fatality. Look for clinical interest instantly if you have high temperature or you are really feeling extremely weak, uneasy or worn out (despair) and also you establish any one of the complying with signs and symptoms in the location in between as well as around your rectum and also genital areas: discomfort or tendernessswelling significant allergy. Quit taking INVOKANA as well as call your physician right away or go to the local medical facility emergency situation area if you have any type of signs and symptoms of a severe sensitive response. See “& ldquo; Do not take INVOKANA if you:”& rdquo;. Your physician might offer you a medication for your allergy and also suggest a various medication for your diabetes mellitus.

One of the most typical negative effects of INVOKANA consist of:

adjustments in peeing, consisting of immediate requirement to pee more frequently, in bigger quantities, or during the night

These are not all the feasible negative effects of INVOKANA.

Call your medical professional for clinical guidance regarding negative effects. You might report adverse effects to FDA at 1-800-FDA-1088.

You might likewise report adverse effects to Janssen Pharmaceuticals, Inc. at 1-800-526-7736.



An about 2-fold enhanced threat of reduced arm or leg amputations connected with INVOKANA usage was observed in CANVAS and also CANVAS-R, 2 huge, randomized, placebo-controlled tests in clients with kind 2 diabetes mellitus that had actually developed heart disease (CVD) or went to danger for CVD. Amputations of the toe as well as midfoot were most constant; nonetheless, amputations including the leg were likewise observed. Some individuals had numerous amputations, some entailing both arm or legs. Prior to launching, take into consideration elements that might raise the threat of amputation, such as a background of previous amputation, outer vascular illness, neuropathy, as well as diabetic person foot abscess.


INVOKANA (canagliflozin) has canagliflozin, a prevention of sodium-glucose co-transporter 2 (SGLT2), the carrier in charge of reabsorbing most of sugar filteringed system by the kidney. Canagliflozin, the energetic component of INVOKANA, is chemically referred to as (ONE)-1,5-anhydro-1- <3- <<5-(4-fluorophenyl)-2-thienyl> methyl> -4-methylphenyl> -D-glucitol hemihydrate as well as its molecular formula and also weight are C24H25FO5S•& bull; & frac12; water as well as 453.53, specifically. The architectural formula for canagliflozin is:


Canagliflozin is almost insoluble in liquid media from pH 1.1 to 12.9.

INVOKANA is provided as film-coated tablet computers for dental management, consisting of 102 and also 306 mg of canagliflozin in each tablet toughness, representing 100 mg and also 300 mg of canagliflozin (anhydrous), specifically.

Non-active components of the core tablet computer are croscarmellose salt, hydroxypropyl cellulose, lactose anhydrous, magnesium stearate, as well as microcrystalline cellulose. The magnesium stearate is vegetable-sourced. The tablet computers are completed with a readily offered film-coating including the complying with excipients: polyvinyl alcohol (partly hydrolyzed), titanium dioxide, macrogol/peg, iron, and also talc oxide yellow, E172 (100 mg tablet computer just).